Colloidal Drug Formulations Can Explain “Bell-Shaped” Concentration–Response Curves
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چکیده
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Colloidal Drug Formulations Can Explain “Bell-Shaped” Concentration–Response Curves
Drug efficacy does not always increase sigmoidally with concentration, which has puzzled the community for decades. Unlike standard sigmoidal curves, bell-shaped concentration-response curves suggest more complex biological effects, such as multiple-binding sites or multiple targets. Here, we investigate a physical property-based mechanism for bell-shaped curves. Beginning with the observation ...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2014
ISSN: 1554-8929,1554-8937
DOI: 10.1021/cb4007584